Oxidative stress and vascular disease
نویسندگان
چکیده
منابع مشابه
Oxidative stress and vascular disease.
Growing evidence indicates that chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is integral in the development of cardiovascular diseases (CVD). These ROS can be released from nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, lipoxygenase, mitochondria, or the uncoupling of nitric oxide synthase in vascular cells. ROS me...
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There is compelling evidence that oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases. In atherosclerosis, hypertension, stroke, diabetes, and heart failure, expression of superoxide is increased in blood vessels, and endothelial vasomotor function is impaired, presumably caused in large part by inactivation of nitric oxide by superoxide. Endothelia...
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Despite the damaging effect on tissues at a high concentration, it has been gradually established that oxidative stress plays a positive role during angiogenesis. In adults, physiological or pathological angiogenesis is initiated by tissue demands for oxygen and nutrients, resulting in a hypoxia/reoxygenation cycle, which, in turn promotes the formation of reactive oxygen species (ROS). The ROS...
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Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...
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REFERENCES 1. Nunomura A, Perry G, Aliev G, et al. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol. 2001;60:759-67. 2. Nunomura A, Tamaoki T, Motohashi N, et al. Neuronal RNA oxidation during aging process and in preclinical Alzheimer disease and mild cognitive impairment. J Neuropathol Exp Neurol. In press. 3. Shi G-X, Liu C-Z, Wang L-P, Guan L-P, Li S-Q. ...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2001
ISSN: 0741-5214
DOI: 10.1067/mva.2001.117588